Madonna and Child 

"Madonna and Child" is a painting by the Italian Early Renaissance artist Domenico Ghirlandaio, currently located in the National Museum of San Matteo in Pisa, Italy. The painting features the Virgin Mary holding the Christ child, who is reaching out to the viewer. The painting depicts the Virgin Mary enthroned with the Christ child, surrounded by angels, highlighting the classical principles of the Early Renaissance, including realism, perspective, and naturalism. The painting is believed to be one of Ghirlandaio's earliest works, showcasing his emerging skills in composition and attention to detail.