Santa Maria Maggiore 

This painting, "Santa Maria Maggiore", by Antoniazzo Romano, depicts the Virgin Mary and Child, a popular subject in Renaissance art. Mary is seated, holding the infant Jesus, who reaches out his hand in a gesture of blessing. The figures are set against a red background, a common choice for highlighting the sacredness of the scene. The painting's ornate frame, featuring floral and geometric patterns, adds to its rich visual appeal, further enhancing the depiction of this iconic religious theme.