St. Jerome 

Andrea del Castagno depicted Saint Jerome, around 1455, accompanied by two figures, all adorned with halos, signifying their sainthood and divine grace within the Christian narrative. The raised gaze and outstretched arms of the central figure are motifs echoing throughout art history, symbolizing spiritual ecstasy and supplication, reminiscent of classical orators beseeching their gods. Consider Bernini's Saint Teresa, where a similar expression conveys a profound divine connection, a motif that has evolved from ancient invocations to Renaissance expressions of religious fervor. Such gestures tap into the collective memory, resonating with primal human urges to connect with the divine, engaging viewers on a deep, subconscious level. This cyclical progression reveals how symbols resurface, evolve, and take on new meanings.